Genetic associations with psychosis and affective disturbance in Alzheimer's disease.

ABSTRACT:

Introduction

Individuals with Alzheimer's disease (AD) commonly experience neuropsychiatric symptoms of psychosis (AD+P) and/or affective disturbance (depression, anxiety, and/or irritability, AD+A). This study's goal was to identify the genetic architecture of AD+P and AD+A, as well as their genetically correlated phenotypes.

Methods

Genome-wide association meta-analysis of 9988 AD participants from six source studies with participants characterized for AD+P AD+A, and a joint phenotype (AD+A+P).

Results

AD+P and AD+A were genetically correlated. However, AD+P and AD+A diverged in their genetic correlations with psychiatric phenotypes in individuals without AD. AD+P was negatively genetically correlated with bipolar disorder and positively with depressive symptoms. AD

SUBMITTER: Antonsdottir IM 

PROVIDER: S-EPMC11114588 | biostudies-literature | 2024 Apr-Jun

REPOSITORIES: biostudies-literature