Identification of putative cancer genes through data integration and comparative genomics between plants and humans.

ABSTRACT: Coordination of cell division with growth and development is essential for the survival of organisms. Mistakes made during replication of genetic material can result in cell death, growth defects, or cancer. Because of the essential role of the molecular machinery that controls DNA replication and mitosis during development, its high degree of conservation among organisms is not surprising. Mammalian cell cycle genes have orthologues in plants, and vice versa. However, besides the many known and characterized proliferation genes, still undiscovered regulatory genes are expected to exist with conserved functions in plants and humans. Starting from genome-wide Arabidopsis thaliana microarray data, an integrative strategy based on coexpression, functional enrichment analysis, and cis-regulato

SUBMITTER: Quimbaya M 

PROVIDER: S-EPMC11114995 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature