5-Year simulation of diabetes-related complications in people treated with tirzepatide or semaglutide versus insulin glargine.

ABSTRACT:

Aim

This study compared the 5-year incidence rate of macrovascular and microvascular complications for tirzepatide, semaglutide and insulin glargine in individuals with type 2 diabetes, using the Building, Relating, Assessing, and Validating Outcomes (BRAVO) diabetes simulation model.

Research design and methods

This study was a 5-year SURPASS-2 trial extrapolation, with an insulin glargine arm added as an additional comparator. The 1-year treatment effects of tirzepatide (5, 10 or 15 mg), semaglutide (1 mg) and insulin glargine on glycated haemoglobin, systolic blood pressure, low-density lipoprotein and body weights were obtained from the SUSTAIN-4 and SURPASS-2 trials. We used the BRAVO model to predict 5-year complications for each study arm under two scenarios: the 1-ye

SUBMITTER: Niu S 

PROVIDER: S-EPMC11115367 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature