Bile Chemistry During Ex Situ Normothermic Liver Perfusion Does Not Always Predict Cholangiopathy.

ABSTRACT:

Background

Bile chemistry during normothermic ex situ liver perfusion (NESLiP) has been suggested to be an indicator of cholangiopathy. The normal range of biochemical variables in bile of livers undergoing NESLiP has not been defined, nor have published biliary viability criteria been assessed against instances of posttransplant nonanastomotic bile strictures (NASs).

Methods

The bile and perfusate chemistry of 200 livers undergoing NESLiP between February 1, 2018, and October 30, 2023, was compared. In addition, 11 livers that underwent NESLiP and later developed NAS were selected and their bile chemistry was also examined.

Results

In livers that did not develop cholangiopathy, concentrations of sodium, potassium, and chloride were slightly higher in bile than in per

SUBMITTER: Watson CJE 

PROVIDER: S-EPMC11115455 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature