An assessment of the mediating role of hypertension in the effect of long-term air pollution exposure on dementia.

ABSTRACT:

Background

Growing evidence links air pollution exposure to the risk of dementia. We hypothesized that hypertension may partially mediate this effect.

Methods

We previously documented an association between air pollution and dementia in the Ginkgo Evaluation of Memory Study, a randomized, placebo-controlled trial of 3069 adults ≥75 years across four US sites who were evaluated for dementia every 6 months from 2000-2008. We utilized a two-stage regression approach for causal mediation analysis to decompose the total effect of air pollution on dementia into its natural direct and indirect effect through prevalent hypertension. Exposure to air pollution in the 10 or 20 years before enrollment was assigned using estimates from fine-scale spatial-temporal models for PM_2.5

SUBMITTER: Libby TE 

PROVIDER: S-EPMC11115980 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature