NETosis Drives Blood Pressure Elevation and Vascular Dysfunction in Hypertension.

ABSTRACT:

Background

Neutrophil extracellular traps (NETs) are composed of DNA, enzymes, and citrullinated histones that are expelled by neutrophils in the process of NETosis. NETs accumulate in the aorta and kidneys in hypertension. PAD4 (protein-arginine deiminase-4) is a calcium-dependent enzyme that is essential for NETosis. TRPV4 (transient receptor potential cation channel subfamily V member 4) is a mechanosensitive calcium channel expressed in neutrophils. Thus, we hypothesize that NETosis contributes to hypertension via NET-mediated endothelial cell (EC) dysfunction.

Methods

NETosis-deficient Padi4^-/- mice were treated with Ang II (angiotensin II). Blood pressure was measured by radiotelemetry, and vascular reactivity was measured with wire myography.

SUBMITTER: Krishnan J 

PROVIDER: S-EPMC11116040 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature