Kidney Function Measures and Mortality: A Mendelian Randomization Study.

ABSTRACT:

Rationale & objective

Individuals with a low estimated glomerular filtration rate (eGFR) are at a high risk of death. However, the causes underpinning this association are largely uncertain. This study aimed to assess the causal relationship of low eGFR with all-cause and cause-specific mortality.

Study design

Retrospective cohort study incorporating Mendelian randomization (MR).

Setting & participants

Individual-level data from 436,214 White participants (54.3% female; aged 56.8±8.0 years) included in the UK Biobank.

Exposures

eGFR estimated using cystatin C (eGFR_cyst).

Outcomes

The outcomes of interest included all-cause mortality, cardiovascular mortality, cancer mortality, infection mortality, and other-cause mortality.

Analytical appro

SUBMITTER: Shan Y 

PROVIDER: S-EPMC11116063 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature