Transcriptomic changes in eutopic endometrium and ectopic lesions during endometriosis progression in a mouse model.

ABSTRACT:

Objective

To identify the transcriptomic changes of ectopic lesions and eutopic endometrial tissues during the progression of endometriosis, we performed transcriptomic analysis in the eutopic endometrium and ectopic lesions.

Design

Laboratory study.

Setting

Academic medical center.

Animals

Four fertile and 4 subfertile Pgr^cre/+Rosa26^mTmG/+ mice with endometriosis, and 4 sham mice for each group of endometriosis mice as control. These mice underwent either surgery to induce endometriosis or sham surgery. Fertile sham and mice with endometriosis were used 1 month after surgery, whereas subfertile ones were used 3 months after surgery.

Interventions

Early and chronic effects of endometriosis on transcriptomics of ectopic lesions and e

SUBMITTER: Li R 

PROVIDER: S-EPMC11116064 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature