Sleep spindle architecture associated with distinct clinical phenotypes in older adults at risk for dementia.

ABSTRACT: Sleep spindles are a hallmark of non-REM sleep and play a fundamental role in memory consolidation. Alterations in these spindles are emerging as sensitive biomarkers for neurodegenerative diseases of ageing. Understanding the clinical presentations associated with spindle alterations may help to elucidate the functional role of these distinct electroencephalographic oscillations and the pathophysiology of sleep and neurodegenerative disorders. Here, we use a data-driven approach to examine the sleep, memory and default mode network connectivity phenotypes associated with sleep spindle architecture in older adults (mean age = 66 years). Participants were recruited from a specialist clinic for early diagnosis and intervention for cognitive decline, with a proportion showing mild cognitive d

SUBMITTER: Orlando IF 

PROVIDER: S-EPMC11116104 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature