Preclinical Proof-of-Concept of a Minimally Invasive Direct Cardiac Compression Device for Pediatric Heart Support.

ABSTRACT:

Purpose

For pediatric patients, extracorporeal membrane oxygenation (ECMO) remains the predominant mechanical circulatory support (MCS) modality for heart failure (HF) although survival to discharge rates remain between 50 and 60% for these patients. The device-blood interface and disruption of physiologic hemodynamics are significant contributors to poor outcomes.

Methods

In this study, we evaluate the preclinical feasibility of a minimally invasive, non-blood-contacting pediatric DCC prototype for temporary MCS. Proof-of-concept is demonstrated in vivo in an animal model of HF. Hemodynamic pressures and flows were examined.

Results

Minimally invasive deployment on the beating heart was successful without cardiopulmonary bypass or anticoagulation. During HF, device o

SUBMITTER: Hord EC 

PROVIDER: S-EPMC11116177 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature