Cognitive trajectories preluding the onset of different dementia entities: a descriptive longitudinal study using the NACC database.

ABSTRACT:

Objective

To describe the 10-year preclinical cognitive trajectories of older, non-demented individuals towards the onset of the four most prevalent types of dementia, i.e., Alzheimer's disease(AD), Lewy body(LBD), vascular(VD) and frontotemporal dementia(FTD).

Methods

Our analysis focused on data from older (≥ 60years) NACC (National Alzheimer's Coordinating Center) participants. Four distinct presymptomatic dementia groups (AD-LBD-VD-FTD) and a comparison group of cognitively unimpaired(CU) participants were formed. Comprehensive cognitive assessments involving verbal episodic memory, semantic verbal fluency, confrontation naming, mental processing speed - attention and executive function - cognitive flexibility were conducted at baseline and on an approximately yearly bas

SUBMITTER: Liampas I 

PROVIDER: S-EPMC11116253 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature