Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium.

ABSTRACT: Using pooled vaginal microbiota data from pregnancy cohorts (N = 683 participants) in the Environmental influences on Child Health Outcomes (ECHO) Program, we analyzed 16S rRNA gene amplicon sequences to identify clinical and demographic host factors that associate with vaginal microbiota structure in pregnancy both within and across diverse cohorts. Using PERMANOVA models, we assessed factors associated with vaginal community structure in pregnancy, examined whether host factors were conserved across populations, and tested the independent and combined effects of host factors on vaginal community state types (CSTs) using multinomial logistic regression models. Demographic and social factors explained a larger amount of variation in the vaginal microbiome in pregnancy than clinical factors

SUBMITTER: McKee K 

PROVIDER: S-EPMC11116393 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature