Proteome-wide Mendelian randomization identifies potential therapeutic targets for nonalcoholic fatty liver diseases.

ABSTRACT: Nonalcoholic fatty liver disease (NAFLD) is the predominant cause of liver pathology. Current evidence highlights plasma proteins as potential therapeutic targets. However, their mechanistic roles in NAFLD remain unclear. This study investigated the involvement of specific plasma proteins and intermediate risk factors in NAFLD progression. Two-sample Mendelian randomization (MR) analysis was conducted to examine the association between plasma proteins and NAFLD. Colocalization analysis determined the shared causal variants between the identified proteins and NAFLD. The MR analysis was applied separately to proteins, risk factors, and NAFLD. Mediator shares were computed by detecting the correlations among these elements. Phenome-wide association studies (phewas) were utilized to assess the

SUBMITTER: Li J 

PROVIDER: S-EPMC11116402 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature