<i>Ascaris suum</i> infection in juvenile pigs elicits a local Th2 response in a setting of ongoing Th1 expansion.

ABSTRACT: Ascaris spp. undergo extensive migration within the body before establishing patent infections in the small intestinal tract of humans and pigs. However, whether larval migration is critical for inducing efficient type 2 responses remains poorly understood. Therefore, we investigated systemic versus local adaptive immune responses along the hepato-tracheal migration of Ascaris suum during primary, single infections in conventionally raised pigs. Neither the initial invasion of gut tissue nor migration through the liver resulted in discernable Th2 cell responses. In contrast, lung-stage larvae elicited a Th2-biased pulmonary response, which declined after the larvae had left the lungs. In the small intestine, we observed an accumulation of Th2 cells upon the arrival of fourth-

SUBMITTER: Oser L 

PROVIDER: S-EPMC11116563 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature