MiR-146a alleviates inflammatory bowel disease in mice through systematic regulation of multiple genetic networks.

ABSTRACT:

Introduction

Inflammatory bowel disease (IBD) is a chronic disease involving multiple genes, and the current available targeted drugs for IBD only deliver moderate efficacy. Whether there is a single gene that systematically regulates IBD is not yet known. MiR-146a plays a pivotal role in repression of innate immunity, but its function in the intestinal inflammation is sort of controversy, and the genetic regulatory networks regulated by miR-146a in IBD has not been revealed.

Methods

RT-qPCR was employed to detect the expression of miR-146a in IBD patients and in a mouse IBD model induced by dextran sulfate sodium (DSS), and then we generated a miR-146a knock-out mouse line with C57/Bl6N background. The disease activity index was scored in DSS-treated mi

SUBMITTER: Zhu F 

PROVIDER: S-EPMC11116640 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature