Uterine leiomyoma causes an increase in systolic blood pressure: a two-sample Mendelian randomization study.

ABSTRACT:

Objectives

Hypertension and hypertensive disorders of pregnancy (HDP) are common diseases in women at different stages, which affect women's physical and mental health, and the impact of the latter on the offspring cannot not be ignored. Observational studies have investigated the correlation between uterine leiomyoma (UL) and the above conditions, but the relationship remains unclear. In this study, we employed two-sample Mendelian randomization (MR) analysis to assess the association between UL and hypertension, HDP, as well as blood pressure.

Methods

We collected genetic association data of UL (35,474 cases), hypertension (129,909 cases), HDP (gestational hypertension with 8,502 cases, pre-eclampsia with 6,663 cases and eclampsia with 452cases), systolic blood pressure (S

SUBMITTER: Xu H 

PROVIDER: S-EPMC11116641 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature