Aberrant adaptive immune response underlies genetic susceptibility to tuberculosis.

ABSTRACT: Mycobacterium tuberculosis (Mtb) remains a major threat worldwide, although only a fraction of infected individuals develops tuberculosis (TB). TB susceptibility is shaped by multiple genetic factors, and we performed comparative immunological analysis of two mouse strains to uncover relevant mechanisms underlying susceptibility and resistance. C57BL/6 mice are relatively TB-resistant, whereas I/St mice are prone to develop severe TB, partly due to the MHC-II allelic variant that shapes suboptimal CD4⁺ T cell receptor repertoire. We investigated the repertoires of lung-infiltrating helper T cells and B cells at the progressed stage in both strains. We found that lung CD4⁺ T cell repertoires of infected C57BL/6 but not I/St mice contained convergent TCR c

SUBMITTER: Tsareva A 

PROVIDER: S-EPMC11116662 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature