Moss-produced human complement factor H with modified glycans has an extended half-life and improved biological activity.

ABSTRACT: Most drugs that target the complement system are designed to inhibit the complement pathway at either the proximal or terminal levels. The use of a natural complement regulator such as factor H (FH) could provide a superior treatment option by restoring the balance of an overactive complement system while preserving its normal physiological functions. Until now, the systemic treatment of complement-associated disorders with FH has been deemed unfeasible, primarily due to high production costs, risks related to FH purified from donors' blood, and the challenging expression of recombinant FH in different host systems. We recently demonstrated that a moss-based expression system can produce high yields of properly folded, fully functional, recombinant FH. However, the half-life of the initial

SUBMITTER: Tschongov T 

PROVIDER: S-EPMC11117068 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature