Subclinical Keratoconus Detection and Characterization Using Motion-Tracking Brillouin Microscopy.

ABSTRACT:

Purpose

To characterize focal biomechanical alterations in subclinical keratoconus (SKC) using motion-tracking (MT) Brillouin microscopy and evaluate the ability of MT Brillouin metrics to differentiate eyes with SKC from normal control eyes.

Design

Prospective cross-sectional study.

Participants

Thirty eyes from 30 patients were evaluated, including 15 eyes from 15 bilaterally normal patients and 15 eyes with SKC from 15 patients.

Methods

All patients underwent Scheimpflug tomography and MT Brillouin microscopy using a custom-built device. Mean and minimum MT Brillouin values within the anterior plateau region and anterior 150 μm were generated. Scheimpflug metrics evaluated included inferior-superior (IS) value, maximum keratometry (K_max), thinnest

SUBMITTER: Randleman JB 

PROVIDER: S-EPMC11117393 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature