A Copper-Selective Sensor and Its Inhibition of Copper-Amyloid Beta Aggregation.

ABSTRACT: Copper is an essential trace metal for biological processes in humans and animals. A low level of copper detection at physiological pH using fluorescent probes is very important for in vitro applications, such as the detection of copper in water or urine, and in vivo applications, such as tracking the dynamic copper concentrations inside cells. Copper homeostasis is disrupted in neurological diseases like Alzheimer's disease, and copper forms aggregates with amyloid beta (Ab42) peptide, resulting in senile plaques in Alzheimer's brains. Therefore, a selective copper detector probe that can detect amyloid beta peptide-copper aggregates and decrease the aggregate size has potential uses in medicine. We have developed a series of Cu²⁺-selective low fluorescent to high fluorescent t

SUBMITTER: Nguyen NK 

PROVIDER: S-EPMC11117483 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature