Metabolic bioactivation of antidepressants: advance and underlying hepatotoxicity.

ABSTRACT: Many drugs that serve as first-line medications for the treatment of depression are associated with severe side effects, including liver injury. Of the 34 antidepressants discussed in this review, four have been withdrawn from the market due to severe hepatotoxicity, and others carry boxed warnings for idiosyncratic liver toxicity. The clinical and economic implications of antidepressant-induced liver injury are substantial, but the underlying mechanisms remain elusive. Drug-induced liver injury may involve the host immune system, the parent drug, or its metabolites, and reactive drug metabolites are one of the most commonly referenced risk factors. Although the precise mechanism by which toxicity is induced may be difficult to determine, identifying reactive metabolites that cause toxicit

SUBMITTER: Khalil SM 

PROVIDER: S-EPMC11118075 | biostudies-literature | 2024 Feb-May

REPOSITORIES: biostudies-literature