Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma.

ABSTRACT: Although many novel gene-metabolite and gene-protein associations have been identified using high-throughput biochemical profiling, systematic studies that leverage human genetics to illuminate causal relationships between circulating proteins and metabolites are lacking. Here, we performed protein-metabolite association studies in 3,626 plasma samples from three human cohorts. We detected 171,800 significant protein-metabolite pairwise correlations between 1,265 proteins and 365 metabolites, including established relationships in metabolic and signaling pathways such as the protein thyroxine-binding globulin and the metabolite thyroxine, as well as thousands of new findings. In Mendelian randomization (MR) analyses, we identified putative causal protein-to-metabolite associations. We expe

SUBMITTER: Benson MD 

PROVIDER: S-EPMC11118091 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature