Genetic basis for conversion of rough-to-smooth colony morphology in Actinobacillus actinomycetemcomitans.

ABSTRACT: The basis of the rough-to-smooth conversion of Actinobacillus actinomycetemcomitans was examined. Smooth variants often contained mutations at the flp promoter region. Replacing the mutated flp promoter with the wild-type promoter restored the rough phenotype. The expression level of the flp promoter was approximately 100-fold lower in smooth than in rough strains. Mutations of the flp promoter are a cause of the rough-to-smooth conversion.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC1111812 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature