Mapping vascular network architecture in primate brain using ferumoxytol-weighted laminar MRI.

ABSTRACT: Mapping the vascular organization of the brain is of great importance across various domains of basic neuroimaging research, diagnostic radiology, and neurology. However, the intricate task of precisely mapping vasculature across brain regions and cortical layers presents formidable challenges, resulting in a limited understanding of neurometabolic factors influencing the brain's microvasculature. Addressing this gap, our study investigates whole-brain vascular volume using ferumoxytol-weighted laminar-resolution multi-echo gradient-echo imaging in macaque monkeys. We validate the results with published data for vascular densities and compare them with cytoarchitecture, neuron and synaptic densities. The ferumoxytol-induced change in transverse relaxation rate ( ΔR2* ), an indirect proxy m

SUBMITTER: Autio JA 

PROVIDER: S-EPMC11118324 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature