The Precision and Power of Population Branch Statistics in Identifying the Genomic Signatures of Local Adaptation.

ABSTRACT: Population branch statistics, which estimate the branch lengths of focal populations with respect to two outgroups, have been used as an alternative to F_ST-based genome-wide scans for identifying loci associated with local selective sweeps. In addition to the original population branch statistic (PBS), there are subsequently proposed branch rescalings: normalized population branch statistic (PBSn1), which adjusts focal branch length with respect to outgroup branch lengths at the same locus, and population branch excess (PBE), which also incorporates median branch lengths at other loci. PBSn1 and PBE have been proposed to be less sensitive to allele frequency divergence generated by background selection or geographically ubiquitous positive selection rather than local selective s

SUBMITTER: Shpak M 

PROVIDER: S-EPMC11118325 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature