Brain-wide functional connectome analysis of 40,000 individuals reveals brain networks that show aging effects in older adults.

ABSTRACT: The functional connectome changes with aging. We systematically evaluated aging related alterations in the functional connectome using a whole-brain connectome network analysis in 39,675 participants in UK Biobank project. We used adaptive dense network discovery tools to identify networks directly associated with aging from resting-state fMRI data. We replicated our findings in 499 participants from the Lifespan Human Connectome Project in Aging study. The results consistently revealed two motor-related subnetworks (both permutation test p-values <0.001) that showed a decline in resting-state functional connectivity (rsFC) with increasing age. The first network primarily comprises sensorimotor and dorsal/ventral attention regions from precentral gyrus, postcentral gyrus, superior temporal

SUBMITTER: Pan Y 

PROVIDER: S-EPMC11118564 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature