Adverse pregnancy outcomes and coronary artery disease risk: A negative control Mendelian randomization study.

ABSTRACT:

Background

Adverse pregnancy outcomes are predictive for future cardiovascular disease risk, but it is unclear whether they play a causal role. We conducted a Mendelian randomization study with males as a negative control population to estimate the associations between genetic liability to adverse pregnancy outcomes and risk of coronary artery disease.

Methods

We extracted uncorrelated (R²<0.01) single-nucleotide polymorphisms strongly associated (p-value<5e-8) with miscarriage, gestational diabetes, hypertensive disorders of pregnancy, preeclampsia, placental abruption, poor fetal growth and preterm birth from relevant genome-wide association studies. Genetic associations with risk of coronary artery disease were extracted separately for females and males. The ma

SUBMITTER: Rogne T 

PROVIDER: S-EPMC11118587 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature