A new lineage nomenclature to aid genomic surveillance of dengue virus.

ABSTRACT: Dengue virus (DENV) is currently causing epidemics of unprecedented scope in endemic settings and expanding to new geographical areas. It is therefore critical to track this virus using genomic surveillance. However, the complex patterns of viral genomic diversity make it challenging to use the existing genotype classification system. Here we propose adding two sub-genotypic levels of virus classification, named major and minor lineages. These lineages have high thresholds for phylogenetic distance and clade size, rendering them stable between phylogenetic studies. We present an assignment tool to show that the proposed lineages are useful for regional, national and sub-national discussions of relevant DENV diversity. Moreover, the proposed lineages are robust to classification using parti

SUBMITTER: Hill V 

PROVIDER: S-EPMC11118645 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature