Modification of Gas6 Protein in the Brain by a Functional Endogenous Tissue Vitamin K Cycle.

ABSTRACT: The TAM receptor ligand Gas6 is known for regulating inflammatory and immune pathways in various organs including the brain. Gas6 becomes fully functional through the post-translational modification of multiple glutamic acid residues into γ-carboxyglutamic in a vitamin K-dependent manner. However, the significance of this mechanism in the brain is not known. We report here the endogenous expression of multiple components of the vitamin K cycle within the mouse brain at various ages as well as in distinct brain glial cells. The brain expression of all genes was increased in the postnatal ages, mirroring their profiles in the liver. In microglia, the proinflammatory agent lipopolysaccharide caused the downregulation of all key vitamin K cycle genes. A secreted Gas6 protein was detected in th

SUBMITTER: Aydin N 

PROVIDER: S-EPMC11119062 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature