Single-Cell Analyses Offer Insights into the Different Remodeling Programs of Arteries and Veins.

ABSTRACT: Arteries and veins develop different types of occlusive diseases and respond differently to injury. The biological reasons for this discrepancy are not well understood, which is a limiting factor for the development of vein-targeted therapies. This study contrasts human peripheral arteries and veins at the single-cell level, with a focus on cell populations with remodeling potential. Upper arm arteries (brachial) and veins (basilic/cephalic) from 30 organ donors were compared using a combination of bulk and single-cell RNA sequencing, proteomics, flow cytometry, and histology. The cellular atlases of six arteries and veins demonstrated a 7.8× higher proportion of contractile smooth muscle cells (SMCs) in arteries and a trend toward more modulated SMCs. In contrast, veins showed a higher ab

SUBMITTER: Rojas MG 

PROVIDER: S-EPMC11119253 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature