Proteomics Identifies LUC7L3 as a Prognostic Biomarker for Hepatocellular Carcinoma.

ABSTRACT: Alternative splicing has been shown to participate in tumor progression, including hepatocellular carcinoma. The poor prognosis of patients with HCC calls for molecular classification and biomarker identification to facilitate precision medicine. We performed ssGSEA analysis to quantify the pathway activity of RNA splicing in three HCC cohorts. Kaplan-Meier and Cox methods were used for survival analysis. GO and GSEA were performed to analyze pathway enrichment. We confirmed that RNA splicing is significantly correlated with prognosis, and identified an alternative splicing-associated protein LUC7L3 as a potential HCC prognostic biomarker. Further bioinformatics analysis revealed that high LUC7L3 expression indicated a more progressive HCC subtype and worse clinical features. Cell prolifer

SUBMITTER: Hou Y 

PROVIDER: S-EPMC11120364 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature