A Bidirectional Non-Coding RNA Promoter Mediates Long-Range Gene Expression Regulation.

ABSTRACT: Recent evidence suggests that human gene promoters display gene expression regulatory mechanisms beyond the typical single gene local transcription modulation. In mammalian genomes, genes with an associated bidirectional promoter are abundant; bidirectional promoter architecture serves as a regulatory hub for a gene pair expression. However, it has been suggested that its contribution to transcriptional regulation might exceed local transcription initiation modulation. Despite their abundance, the functional consequences of bidirectional promoter architecture remain largely unexplored. This work studies the long-range gene expression regulatory role of a long non-coding RNA gene promoter using chromosome conformation capture methods. We found that this particular bidirectional promoter con

SUBMITTER: Peralta-Alvarez CA 

PROVIDER: S-EPMC11120797 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature