Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals.

ABSTRACT: Individuals of admixed ancestries (for example, African Americans) inherit a mosaic of ancestry segments (local ancestry) originating from multiple continental ancestral populations. This offers the unique opportunity of investigating the similarity of genetic effects on traits across ancestries within the same population. Here we introduce an approach to estimate correlation of causal genetic effects (r_admix) across local ancestries and analyze 38 complex traits in African-European admixed individuals (N = 53,001) to observe very high correlations (meta-analysis r_admix = 0.95, 95% credible interval 0.93-0.97), much higher than correlation of causal effects across continental ancestries. We replicate our results using regression-based methods from marginal genome-wide

SUBMITTER: Hou K 

PROVIDER: S-EPMC11120833 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature