Genome-Wide Epistatic Network Analyses of Semantic Fluency in Older Adults.

ABSTRACT: Semantic fluency impairment has been attributed to a wide range of neurocognitive and psychiatric conditions, especially in the older population. Moderate heritability estimates on semantic fluency were obtained from both twin and family-based studies suggesting genetic contributions to the observed variation across individuals. Currently, effort in identifying the genetic variants underlying the heritability estimates for this complex trait remains scarce. Using the semantic fluency scale and genome-wide SNP genotype data from the Long Life Family Study (LLFS), we performed a genome-wide association study (GWAS) and epistasis network analysis on semantic fluency in 2289 individuals aged over 60 years from the American LLFS cohorts and replicated the findings in 1129 individuals aged over

SUBMITTER: Tan Q 

PROVIDER: S-EPMC11120839 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature