Comparative Genome-Wide Alternative Splicing Analysis between Preadipocytes and Adipocytes.

ABSTRACT: Alternative splicing is a ubiquitous regulatory mechanism in gene expression that allows a single gene to generate multiple messenger RNAs (mRNAs). Adipocyte development is regulated by many processes, and recent studies have found that splicing factors also play an important role in adipogenic development. In the present study, we further investigated the differences in selective shearing during different periods of adipocyte differentiation. We identified five alternative splicing types including skipped exon, mutually exclusive exon, Alternative 5' splice site, Alternative 3' splice site, and Retained intron, with skipped exons being the most abundant type of selective shearing. In total, 641 differentially expressed selective shearing genes were obtained, enriched in 279 pathways, from

SUBMITTER: Hou Z 

PROVIDER: S-EPMC11121090 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature