Transcriptome Analysis of BAFF/BAFF-R System in Murine Nephrotoxic Serum Nephritis.

ABSTRACT: Chronic kidney disease (CKD) is an emerging cause for morbidity and mortality worldwide. Acute kidney injury (AKI) can transition to CKD and finally to end-stage renal disease (ESRD). Targeted treatment is still unavailable. NF-κB signaling is associated with CKD and activated by B cell activating factor (BAFF) via BAFF-R binding. In turn, renal tubular epithelial cells (TECs) are critical for the progression of fibrosis and producing BAFF. Therefore, the direct involvement of the BAFF/BAFF-R system to the pathogenesis of CKD is conceivable. We performed non-accelerated nephrotoxic serum nephritis (NTN) as the CKD model in BAFF KO (B6.129S2-Tnfsf13b^tm1Msc/J), BAFF-R KO (B6(Cg)-Tnfrsf13c^tm1Mass/J) and wildtype (C57BL/6J) mice to analyze the BAFF/BA

SUBMITTER: Mockel T 

PROVIDER: S-EPMC11121395 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature