A Hadal Streptomyces-Derived Echinocandin Acylase Discovered through the Prioritization of Protein Families.

ABSTRACT: Naturally occurring echinocandin B and FR901379 are potent antifungal lipopeptides featuring a cyclic hexapeptide nucleus and a fatty acid side chain. They are the parent compounds of echinocandin drugs for the treatment of severe fungal infections caused by the Candida and Aspergilla species. To minimize hemolytic toxicity, the native fatty acid side chains in these drug molecules are replaced with designer acyl side chains. The deacylation of the N-acyl side chain is, therefore, a crucial step for the development and manufacturing of echinocandin-type antibiotics. Echinocandin E (ECE) is a novel echinocandin congener with enhanced stability generated via the engineering of the biosynthetic machinery of echinocandin B (ECB). In the present study, we report the discove

SUBMITTER: Jiang X 

PROVIDER: S-EPMC11122479 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature