Marine Prostanoids with Cytotoxic Activity from Octocoral Clavularia spp.

ABSTRACT: Octocoral of the genus Clavularia is a kind of marine invertebrate possessing abundant cytotoxic secondary metabolites, such as prostanoids and dolabellanes. In our continuous natural product study of C. spp., two previously undescribed prostanoids [clavulone I-15-one (1) and 12-O-deacetylclavulone I (2)] and eleven known analogs (3-13) were identified. The structures of these new compounds were elucidated based on analysis of their 1D and 2D NMR, HRESIMS, and IR data. Additionally, all tested prostanoids (1 and 3-13) showed potent cytotoxic activities against the human oral cancer cell line (Ca9-22). The major compound 3 showed cytotoxic activity against the Ca9-22 cells with the IC₅₀ value of 2.11 ± 0

SUBMITTER: Cheng MY 

PROVIDER: S-EPMC11122631 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature