Effect of Stevioside (<i>Stevia rebaudiana</i>) on <i>Entamoeba histolytica</i> Trophozoites.

ABSTRACT: Human amoebiasis still represents a major health problem worldwide. Metronidazole has been used as the most common drug to treat the disease; however, it is also known that the drug causes undesirable side effects. This has led to the search for new pharmacological alternatives which include phytochemical compounds with antiamoebic effects. We analyzed the amoebicidal activity of stevioside (STV), a diterpene glycoside present in Stevia rebaudiana, on trophozoites of E. histolytica. Different concentrations of STV were tested, and an inhibitory concentration of 50% of cell viability (IC₅₀) was determined with an exposition of 9.53 mM for 24 h. Trophozoites exposed to STV showed morphological changes evidenced by the decrease in the basic structures related to the m

SUBMITTER: Ortega-Carballo KJ 

PROVIDER: S-EPMC11123825 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature