Antimicrobial Functionalization of Silicone-graft-poly(N-vinylimidazole) Catheters.

ABSTRACT: In this work, we present the modification of a medical-grade silicone catheter with the N-vinylimidazole monomer using the grafting-from method at room temperature and induced by gamma rays. The catheters were modified by varying the monomer concentration (20-100 vol%) and the irradiation dose (20-100 kGy). Unlike the pristine material, the grafted poly(N-vinylimidazole) chains provided the catheter with hydrophilicity and pH response. This change allowed for the functionalization of the catheters to endow it with antimicrobial features. Thus, the quaternization of amines with iodomethane and bromoethane was performed, as well as the immobilization of silver and ampicillin. The inhibitory capacity of these materials, functionalized with antimicrobial agents, was challenged ag

SUBMITTER: Navarrete-German LE 

PROVIDER: S-EPMC11123943 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature