Myricetin Acts as an Inhibitor of Type II NADH Dehydrogenase from Staphylococcus aureus.

ABSTRACT:

Background

Staphylococcus aureus is a common pathogenic microorganism in humans and animals. Type II NADH oxidoreductase (NDH-2) is the only NADH:quinone oxidoreductase present in this organism and represents a promising target for the development of anti-staphylococcal drugs. Recently, myricetin, a natural flavonoid from vegetables and fruits, was found to be a potential inhibitor of NDH-2 of S. aureus. The objective of this study was to evaluate the inhibitory properties of myricetin against NDH-2 and its impact on the growth and expression of virulence factors in S. aureus.

Results

A screening method was established to identify effective inhibitors of NDH-2, based on heterologously expressed S. aureus NDH-2. Myricetin was found to be an effecti

SUBMITTER: Zhou JL 

PROVIDER: S-EPMC11124336 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature