Unique bile acid profiles in the bile ducts of patients with primary sclerosing cholangitis.

ABSTRACT:

Background

The relationship between primary sclerosing cholangitis (PSC) and biliary bile acids (BAs) remains unclear. Although a few studies have compared PSC biliary BAs with other diseases, they did not exclude the influence of cholestasis, which affects the composition of BAs. We compared biliary BAs and microbiota among patients with PSC, controls without cholestasis, and controls with cholestasis, based on the hypothesis that alterations in BAs underlie the pathophysiology of PSC.

Methods

Bile samples were obtained using endoscopic retrograde cholangiopancreatography from patients with PSC (n = 14), non-hepato-pancreato-biliary patients without cholestasis (n = 15), and patients with cholestasis (n = 13).

Results

The BA profiles showed that patients with PSC and

SUBMITTER: Kayashima A 

PROVIDER: S-EPMC11124737 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature