A comparative study of blood cell count in four automated hematology analyzers: An evaluation of the impact of preanalytical factors.

ABSTRACT: Differential white blood cell counts are frequently used in diagnosis, patient stratification, and treatment selection to optimize therapy responses. Referral laboratories are often used but challenged with use of different hematology platforms, variable blood shipping times and storage conditions, and the different sensitivities of specific cell types. To extend the scientific literature and knowledge on the temporal commutability of blood samples between hematology analyzers, we performed a comparative ex-vivo study using four of the most utilized commercial platforms, focusing on the assessment of eosinophils given its importance in asthma management. Whole blood from healthy volunteers with and without atopy (n = 6+6) and participants with eosinophilic asthma (n = 6) were stored under

SUBMITTER: Astrand A 

PROVIDER: S-EPMC11125483 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature