Reconstruction of Avian Reovirus History and Dispersal Patterns: A Phylodynamic Study.

ABSTRACT: Avian reovirus (ARV) infection can cause significant losses to the poultry industry. Disease control has traditionally been attempted mainly through vaccination. However, the increase in clinical outbreaks in the last decades demonstrated the poor effectiveness of current vaccination approaches. The present study reconstructs the evolution and molecular epidemiology of different ARV genotypes using a phylodynamic approach, benefiting from a collection of more than one thousand sigma C (σC) sequences sampled over time at a worldwide level. ARVs' origin was estimated to occur several centuries ago, largely predating the first clinical reports. The origins of all genotypes were inferred at least one century ago, and their emergence and rise reflect the intensification of the poultry industry.

SUBMITTER: Franzo G 

PROVIDER: S-EPMC11125613 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature