Local Immune Activation and Age Impact on Humoral Immunity in Mice, with a Focus on IgG Sialylation.

ABSTRACT: Age alters the host's susceptibility to immune induction. Humoral immunity with circulating antibodies, particularly immunoglobulin G (IgG), plays an essential role in immune response. IgG glycosylation in the fragment crystallizable (Fc) region, including sialylation, is important in regulating the effector function by interacting with Fc gamma receptors (FcγRs). Glycosylation is fundamentally changed with age and inflammatory responses. We aimed to explore the regulation of humoral immunity by comparing responses to antigen-induced immune challenges in young and adult mice using a local antigen-induced arthritis mouse model. This study examines the differences in immune response between healthy and immune-challenged states across these groups. Our initial assessment of the arthritis mode

SUBMITTER: Gupta P 

PROVIDER: S-EPMC11125885 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature