Human Dendritic Cell Maturation Is Modulated by Leishmania mexicana through Akt Signaling Pathway.

ABSTRACT: Dendritic cells (DC) along with macrophages are the main host cells of the intracellular parasite Leishmania. DC traverse a process of maturation, passing through an immature state with phagocytic ability to a mature one where they can modulate the immune response through the secretion of cytokines. Several studies have demonstrated that Leishmania inhibits DC maturation. Nevertheless, when cells are subjected to a second stimulus such as LPS/IFN-γ, they manage to mature. In the maturation process of DC, several signaling pathways have been implicated, importantly MAPK. On the other hand, Akt is a signaling pathway deeply involved in cell survival. Some Leishmania species have shown to activate MAPK and Akt in different cells. The aim of this work was to investigate th

SUBMITTER: Rodriguez-Gonzalez J 

PROVIDER: S-EPMC11126033 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature