Peptide Toxins from Antarctica: The Nemertean Predator and Scavenger <i>Parborlasia corrugatus</i> (McIntosh, 1876).

ABSTRACT: Peptide toxins from marine invertebrates have found use as drugs and in biotechnological applications. Many marine habitats, however, remain underexplored for natural products, and the Southern Ocean is among them. Here, we report toxins from one of the top predators in Antarctic waters: the nemertean worm Parborlasia corrugatus (McIntosh, 1876). Transcriptome mining revealed a total of ten putative toxins with a cysteine pattern similar to that of alpha nemertides, four nemertide-beta-type sequences, and two novel full-length parborlysins. Nemertean worms express toxins in the epidermal mucus. Here, the expression was determined by liquid chromatography combined with mass spectrometry. The findings include a new type of nemertide, 8750 Da, containing eight cysteines. In addition, w

SUBMITTER: Jacobsson E 

PROVIDER: S-EPMC11126048 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature