Role of the β₂-adrenergic receptor in podocyte injury and recovery.

ABSTRACT:

Background

Podocytes have a remarkable ability to recover from injury; however, little is known about the recovery mechanisms involved in this process. We recently showed that formoterol, a long-acting β₂-adrenergic receptor (β₂-AR) agonist, induced mitochondrial biogenesis (MB) in podocytes and led to renoprotection in mice. However, it is not clear whether this effect was mediated by formoterol acting through the β₂-AR or if it occurred through "off-target" effects.

Methods

We genetically deleted the β₂-AR specifically in murine podocytes and used these mice to determine whether formoterol acting through the podocyte β₂-AR alone is sufficient for recovery of renal filtration function following injury. The podocyte-spec

SUBMITTER: Arif E 

PROVIDER: S-EPMC11126448 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature