Comparison of CTX-M encoding plasmids present during the early phase of the ESBL pandemic in western Sweden.

ABSTRACT: Plasmids encoding bla_CTX-M genes have greatly shaped the evolution of E. coli producing extended-spectrum beta-lactamases (ESBL-E. coli) and adds to the global threat of multiresistant bacteria by promoting horizontal gene transfer (HGT). Here we screened the similarity of 47 bla_CTX-M -encoding plasmids, from 45 epidemiologically unrelated and disperse ESBL-E. coli strains, isolated during the early phase (2009-2014) of the ESBL pandemic in western Sweden. Using optical DNA mapping (ODM), both similar and rare plasmids were identified. As many as 57% of the plasmids formed five ODM-plasmid groups of at least three similar plasmids per group. The most prevalent type (28%, IncIl, pMLST37) encoded bla_CTX-M-15 (n = 10), bla_CTX-M-3 (n = 2) or bla

SUBMITTER: Wranne MS 

PROVIDER: S-EPMC11126669 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature