Long-term exposure to PM_2.5 leads to mitochondrial damage and differential expression of associated circRNA in rat hepatocytes.

ABSTRACT: Fine particulate matter (PM_2.5) is one of the four major causes of mortality globally. The objective of this study was to investigate the mechanism underlying liver injury following exposure to PM_2.5 and the involvement of circRNA in its regulation. A PM_2.5 respiratory tract exposure model was established in SPF SD male rats with a dose of 20 mg/kg, and liver tissue of rats in control group and PM_2.5-exposed groups rats were detected. The results of ICP-MS showed that Mn, Cu and Ni were enriched in the liver. HE staining showed significant pathological changes in liver tissues of PM_2.5-exposed group, transmission electron microscopy showed significant changes in mitochondrial structure of liver cells, and further mitochondrial function

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11126672 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature